In most situations, any safety hazards will usually be confined to mechanical issues, not structural issues. To the extent that the structure has safety issues, they are almost always easily understood if not easily corrected. Examples are stair handrails and fire-escape doors.
Of course, if a Professional Engineer sees a safety hazard, he or she is required to report it to the owner, especially if it is imminent. What is an engineer to do if there is no one at the house?
There are only two serious sources of structural danger to wood-frame houses: fire and water. Houses burn down every day. What fire does not destroy, water takes over.
Have you ever heard of a house that was destroyed because the foundation had not been underpinned? I suspect not. I certainly have heard of one.